CTCAE Term Grade Definition Anemia A disorder characterized by a reduction in the amount of hemoglobin in 100 ml of blood. Signs and symptoms of anemia may include pallor of the skin and mucous membranes, shortness of breath, palpitations of the heart, soft systolic murmurs, lethargy, and fatigability. 1 Hemoglobin (Hgb) < LLN -10.0 g/dL; 25-<50% reduction from normal cellularity for age 3 Severely hypocellular or >50-<=75% reduction cellularity from normal for age 4 Aplastic persistent for longer than 2 weeks 5 Death Disseminated intravascular coagulation (DIC) A disorder characterized by systemic pathological activation of blood clotting mechanisms which results in clot formation throughout the body. There is an increase in the risk of hemorrhage as the body is depleted of platelets and coagulation factors. 1 NA 2 Laboratory findings with no bleeding 3 Laboratory findings and bleeding 4 Life-threatening consequences. Urgent intervention indicated. 5 Death Eosinophilia A disorder characterized by laboratory test results that indicate an increased number of eosinophils in the blood. 1 > ULN and >baseline 2 NA 3 Steroids initiated 4 NA 5 NA Febrile neutropenia 1 NA 2 NA 3 ANC <1000/mm 3 with a single temperature of >38.3 °C (101 °F) or a sustained temperature of >=38 °C (100.4 °F) for more than one hour 4 Life-threatening consequences. Urgent intervention indicated. 5 Death Hemolysis A disorder characterized by laboratory test results that indicate widespread erythrocyte cell membrane destruction. 1 Laboratory evidence of hemolysis only (e.g., direct antiglobulin test; DAT; Coombs'; schistocytes; decreased haptoglobin) 2 Evidence of hemolysis and <=2 g decrease in hemoglobin 3 Transfusion or medical intervention indicated (e.g., steroids) 4 Life-threatening consequences. Urgent intervention indicated. 5 Death Hemolytic uremic syndrome A disorder characterized by a form of thrombotic microangiopathy with renal failure, hemolytic anemia, and severe thrombocytopenia. 1 NA 2 NA 3 Laboratory findings with clinical consequences (e.g., renal insufficiency, petechiae) 4 Life-threatening consequences (e.g., CNS hemorrhage or thrombosis/embolism or renal failure) 5 Death Leukocytosis A disorder characterized by laboratory test results that indicate an increased number of white blood cells in the blood. 1 NA 2 NA 3 >100,000/mm 3 4 Clinical manifestations of leukostasis. Urgent intervention indicated. 5 Death Lymph node pain A disorder characterized by a sensation of marked discomfort in a lymph node. 1 Mild pain 2 Moderate pain. Limiting instrumental ADL. 3 Severe pain. Limiting self care ADL. 4 NA 5 NA Methemoglobinemia A disorder characterized by laboratory test results that indicate increased methemoglobin in the blood. 1 NA 2 >ULN 3 Requiring urgent intervention 4 Life-threatening consequences 5 Death Thrombotic thrombocytopenic purpura (TTP) A disorder characterized by the presence of microangiopathic hemolytic anemia, thrombocytopenic purpura, fever, renal abnormalities and neurological abnormalities such as seizures, hemiplegia, and visual disturbances. It is an acute or subacute condition. 1 NA 2 NA 3 Laboratory findings with clinical consequences (e.g., renal insufficiency, petechiae) 4 Life-threatening consequences (e.g., CNS hemorrhage or thrombosis/embolism or renal failure) 5 Death Blood and lymphatic system disorders - Other, specify 1 Asymptomatic or mild symptoms. Clinical or diagnostic observations only. Intervention not indicated. 2 Moderate. Minimal, local or noninvasive intervention indicated. Limiting age-appropriate instrumental ADL. 3 Severe or medically significant but not immediately life-threatening. Hospitalization or prolongation of existing hospitalization indicated. Limiting self care ADL. 4 Life-threatening consequences. Urgent intervention indicated. 5 Death

CTCAE (Advers Olay Derecelendirme)

Kan ve lenfatik sistem bozuklukları

Kaynaklar

CTCAE (Advers Olay Derecelendirme)

Kan ve lenfatik sistem bozuklukları

Kaynaklar